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Welcome to the Rosetta Commons GitHub Organization!

Rosetta Commons drives innovation in biomolecular modeling and design through cutting-edge computational methods and shared software. Our global community of scientists collaborates to advance open, reproducible science and accelerate discovery.

This GitHub organization hosts the tools our community has built – from the original physics-based Rosetta software to the latest ML-driven methods for protein design.

What you'll find here

  • Physics-based tools: The original Rosetta suite for structure prediction, docking, and design
  • ML-based tools: Community-built deep learning methods developed over the past several years
  • Support resources: Documentation and community guidance for every experience level

Getting Started

Not sure where to begin? The Software Download page has an overview of all available repositories with their support levels, so you can find the right tool for your pipeline. For broader context on our organization and mission, visit the Rosetta Commons website.

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  1. rosetta rosetta Public

    The Rosetta Bio-macromolecule modeling package. Available through license with the University of Washington.

    C++ 471 170

  2. PyRosetta.notebooks PyRosetta.notebooks Public

    Jupyter Notebooks for learning the PyRosetta platform for biomolecular structure prediction and design

    Jupyter Notebook 709 173

  3. RFdiffusion RFdiffusion Public

    Code for running RFdiffusion

    Python 3.1k 647

  4. binder binder Public

    Binder, tool for automatic generation of Python bindings

    C++ 368 72

  5. foundry foundry Public

    Central repository for biomolecular foundation models with shared trainers and pipeline components

    Python 970 183

  6. atomworks atomworks Public

    A generalized computational framework for biomolecular modeling.

    Python 448 52

Repositories

Showing 10 of 52 repositories
  • RFDiffusion2_all_the_code Public

    This is all of the code for RFDiffusion2. (i.e. git push from the IPD's current repo)

    RosettaCommons/RFDiffusion2_all_the_code's past year of commit activity
    Python 8 2 0 0 Updated Sep 23, 2026
  • rosetta Public

    The Rosetta Bio-macromolecule modeling package. Available through license with the University of Washington.

    RosettaCommons/rosetta's past year of commit activity
    C++ 471 170 25 29 Updated Sep 22, 2026
  • PyRosetta.notebooks Public

    Jupyter Notebooks for learning the PyRosetta platform for biomolecular structure prediction and design

    RosettaCommons/PyRosetta.notebooks's past year of commit activity
    Jupyter Notebook 709 MIT 173 29 6 Updated Sep 19, 2026
  • foundry Public

    Central repository for biomolecular foundation models with shared trainers and pipeline components

    RosettaCommons/foundry's past year of commit activity
    Python 970 BSD-3-Clause 183 77 (1 issue needs help) 11 Updated Sep 8, 2026
  • HBDesigner Public

    HBDesigner is an algorithm that designs highly-connected hydrogen bonding networks that fit the requested design constraints onto an input protein backbone.

    RosettaCommons/HBDesigner's past year of commit activity
    Python 20 MIT 0 0 0 Updated Aug 31, 2026
  • pyrosetta_viewer3d Public

    Display PackedPose objects, Pose objects, or PDB files within a Jupyter notebook and Google Colab

    RosettaCommons/pyrosetta_viewer3d's past year of commit activity
    Python 11 MIT 3 5 0 Updated Aug 29, 2026
  • atomworks Public

    A generalized computational framework for biomolecular modeling.

    RosettaCommons/atomworks's past year of commit activity
    Python 448 BSD-3-Clause 52 24 10 Updated Aug 20, 2026
  • pyrosetta-extras Public

    PyRosetta Extras: a repository for extra PyRosetta scripts, tools, unit testing, and documentation

    RosettaCommons/pyrosetta-extras's past year of commit activity
    Python 0 MIT 1 0 0 Updated Aug 11, 2026
  • RFdiffusion Public

    Code for running RFdiffusion

    RosettaCommons/RFdiffusion's past year of commit activity
    Python 3,057 646 222 23 Updated Jul 16, 2026
  • documentation Public

    Documentation for Rosetta Applications. The source for the Rosetta documentation wiki.

    RosettaCommons/documentation's past year of commit activity
    PostScript 10 5 2 15 Updated Jul 2, 2026